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Minimum Required Performance Limits (MRPL) are relevant only to non-threshold substances and all WADA-accredited laboratories are required to detect prohibited substances at these levels. The reporting of Adverse Analytical Findings may result from concentrations of prohibited substances below these MRPL.
The changes see many MRPLs modified to reflect the increased capability of laboratories to detect prohibited substances at lower levels. This primarily has seen a lowering of MRPLs.
One notable exception is in the stimulants category where octopamine has been given a higher MRPL to avoid reporting positive findings that may have been caused by the ingestion of certain foodstuffs (e.g. citrics and chocolate). Octopamine has an MRPL ten times higher than other non-threshold stimulants.
WADA definition: non-threshold substance
A substance listed on the Prohibited List for which the documentable detection of any amount is considered an adverse analytical finding.